Artificial intelligence (AI) can be trained to recognize whether a tissue image contains a tumor. However, exactly how it makes its decision has remained a mystery until now. A team from the Research Center for Protein Diagnostics (PRODI) at Ruhr-Universität Bochum is developing a new approach that will render an AI’s decision transparent and thus trustworthy. The researchers led by Professor Axel Mosig describe the approach in the journal Medical Image Analysis.